Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response.

Academic Article

Abstract

  • Mechanical loading of muscles by intrinsic muscle activity or passive stretch leads to an increase in the production of reactive oxygen species. The NAD-dependent protein deacetylase SIRT1 is involved in the protection against oxidative stress by enhancing FOXO-driven Sod2 transcription. In this report, we unravel a mechanism triggered by mechanical stretch of skeletal muscle cells that leads to an EGR1-dependent transcriptional activation of the Sirt1 gene. The resulting transient increase in SIRT1 expression generates an antioxidative response that contributes to reactive oxygen species scavenging.

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    Published In

    Keywords

  • Animals, Antioxidants, Cell Line, Early Growth Response Protein 1, Humans, Mice, Muscle Cells, Muscle Proteins, Muscle Stretching Exercises, Muscle, Skeletal, Oxidative Stress, Reactive Oxygen Species, Sirtuin 1, Superoxide Dismutase, Transcription, Genetic

    • Digital Object Identifier (doi)

    Author List

  • Pardo PS; Mohamed JS; Lopez MA; Boriek AM

    • Start Page

  • 2559

    • End Page

  • 2566

    • Volume

  • 286

    • Issue

  • 4