Viremia copy-years and mortality among combination antiretroviral therapy-initiating HIV-positive individuals: how much viral load history is enough?

Academic Article

Abstract

  • OBJECTIVE: Ongoing HIV replication while receiving combination antiretroviral therapy (cART) may reduce survival. Viremia copy-years (VCY) has shown improved mortality risk prediction over single time-point viral load measures. However, the timing of a patient's viral load history most associated with later mortality has not been studied. Here we determined the optimal duration and temporality of viral load history for predicting mortality.DESIGN: Survival analysis among HIV-positive men who initiated cART in the Multicenter AIDS Cohort Study (1995-2015).METHODS: VCY measures were derived from area-under-the-viral load-curve. The overall VCY based upon the complete post-cART viral load history was compared with 20 VCYs derived from viral loads assessed during different shorter time periods (the most recent 1-10 years and initial 1-10 years following cART initiation) for associations with mortality.RESULTS: Each 10-fold increase in VCYs based on the most recent 3-8 years was significantly associated with 23-26% decrease in survival times, a magnitude of effect greater than that of the most recent viral load (16%). These associations were independent of CD4 cell count and single time-point viral loads. In addition, the degree of pre-cART immunodeficiency did not affect the mortality prognostic value of VCY based on viral loads in the most recent 3 years. Conversely, the overall VCY and VCYs based on viral loads immediately following cART initiation were not independent predictors of mortality.CONCLUSION: Among cART-treated men, VCY based upon viral loads in the recent 3 years (six viral loads) has a mortality prognostic value greater than that of the overall VCY and single time-point viral loads, making the former a more feasible measure for use.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 23098373
  • Author List

  • Wang R; Haberlen SA; Palella FJ; Mugavero MJ; Margolick JB; Macatangay BJC; Martínez-Maza O; Jacobson LP; Abraham AG
  • Start Page

  • 2547
  • End Page

  • 2556
  • Volume

  • 32
  • Issue

  • 17