In vitro activities of the benzoquinolizine fluoroquinolone levonadifloxacin (WCK 771) and other antimicrobial agents against mycoplasmas and ureaplasmas in humans, including isolates with defined resistance mechanisms

Academic Article

Abstract

  • Levonadifloxacin (WCK 771) was evaluated against 68 type strains and clinical isolates of Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma spp. in comparison with moxifloxacin, levofloxacin, tetracycline, and azithromycin or clindamycin. Levonadifloxacin MICs were 0.5 g/ml for M. genitalium. MIC90s were 1 g/ml for M. hominis, 0.125 g/ml for M. pneumoniae, and 2 g/ml for Ureaplasma spp. Levonadifloxacin merits further study for treating infections caused by these organisms.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Xue G; Crabb DM; Xiao L; Liu Y; Waites KB
  • Volume

  • 62
  • Issue

  • 11