Concise route to the key intermediate for divergent synthesis of C7-substituted fluoroquinolone derivatives

Academic Article

Abstract

  • A concise route to ethyl 7-bromo-1-cyclopropyl-6,8-difluoro-4-quinolone-3-carboxylate has been developed. This compound is a key intermediate for divergent synthesis of various C7-substituted fluoroquinolones, a group of potent topoisomerase II inhibitors with promising clinical applications. © 2009 Elsevier Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Zhang X; Mu F; Robinson B; Wang P
  • Start Page

  • 600
  • End Page

  • 601
  • Volume

  • 51
  • Issue

  • 4