All-trans-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis

Academic Article


  • A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-expression of chimeric BCL/ABL and PML/RARĪ± translocations by karyotyping, fluorescence in situ hybridization, and quantitative real-time polymerase chain reaction. Promyelocytic blast crisis of CML is a rare event with historically poor outcomes. Treatment of our patient with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) resulted in complete morphologic remission. We review here the relevant literature of promyelocytic blast crisis and highlight the potential of ATRA/ATO as first line management.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 18368282
  • Author List

  • Colvin TA; Vachhani P; Sait S; Neppalli V; Wang ES
  • Start Page

  • 16
  • End Page

  • 19
  • Volume

  • 10