Early restriction of the human antibody repertoire

Academic Article

Abstract

  • Diversification of the antibody repertoire in mammals results from a series of apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that the adult repertoire of antibody specificities is acquired in a developmentally programmed fashion. As previously shown, rearrangement of the gene segments encoding the heavy-chain variable regions (VH) of mouse antibodies is also developmentally ordered: the number of VH gene segments rearranged in B lymphocytes of fetal mice is small but increases progressively after birth. In this report, human fetal B-lineage cells were also shown to rearrange a highly restricted set of VH gene segments. In a sample of heavy-chain transcripts from a 130-day human fetus the most frequently expressed human VH element proved to be closely related to the VH element most fequently expressed in murine fetal B-lineage cells. These observations are important in understanding the development of immunocompetence.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Schroeder HW; Hillson JL; Perlmutter RM
  • Start Page

  • 791
  • End Page

  • 793
  • Volume

  • 238
  • Issue

  • 4828