IgA nephropathy was first described by Berger in 1969.1 The disease is characterized pathologically by the deposition of IgA in the glomerular mesangium. At clinical presentation the disorder may be macroscopic hematuria, often recurring in association with viral upper respiratory illness or with microscopic hematuria or proteinuria (or both). The original concept that IgA nephropathy was a benign form of glomerulonephritis2345 has been reassessed in the light of numerous reports of progression to renal insufficiency.678910 The prevalence of the disease apparently varies greatly among different ethnic groups and nationalities.123,7,8,11,12 Some of the identified pathogenic factors include circulating IgA-containing immune complexes,. © 1985, Massachusetts Medical Society. All rights reserved.