A randomized, double-blinded trial evaluating the efficacy and tolerability of vectical ointment (calcitriol 3 mcg/g ointment) when compared to betamethasone diproprionate ointment (64 mg/g) in patients with nail psoriasis.

Academic Article


  • OBJECTIVES: To demonstrate the efficacy and safety of calcitriol ointment (3 mcg/g) compared to betamethasone diproprionate ointment in the treatment of nail psoriasis. DESIGN: Single-center, double-blind study. SETTING: One academic center. PARTICIPANTS: 10 adult male and female subjects with psoriasis of the fingernails and/or toenails. MEASUREMENTS: The primary efficacy evaluation was the absolute reduction of nail thickness (mm) of the target nail. A secondary endpoint was the improvement in the Physician Global Assessment score of disease severity. RESULTS: Patients treated with either betamethasone diproprionate ointment or calcitriol ointment demonstrated a similar reduction of nail thickness of the selected target nail. The difference between the two groups was not statistically significant (P=0.42). CONCLUSION: This small study illustrates that calcitriol ointment may be as effective as betamethasone diproprionate in the treatment of nail psoriasis, and its promise should be further investigated in a subsequent larger trial.
  • Published In


  • Administration, Cutaneous, Adult, Anti-Inflammatory Agents, Betamethasone, Calcitriol, Double-Blind Method, Female, Humans, Male, Nail Diseases, Ointments, Psoriasis, Treatment Outcome
  • Author List

  • Kole L; Cantrell W; Elewski B
  • Start Page

  • 912
  • End Page

  • 915
  • Volume

  • 13
  • Issue

  • 8