Extreme shear rate dependence of leukocyte rolling in CD18-/-E-selectin/-double mutant mice

Academic Article


  • A study was carried out to examine the impact of shear rate on slow leukocyte rolling and subsequent adhesion in C57BL/6 mice lacking CD18 integrins (CD18-/-), and/or E-selectin (CD62E-/-) using a TNF╬▒-induced model of inflammation of the mouse cremaster muscle. In general, the combined deficiency of CD18 and E-selectin produced the most severe reduction of neutrophil recruitment in any mouse model described so far.
  • Authors

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    Author List

  • Forlow B; Bullard D; Beaudet A; Ley K
  • Volume

  • 28
  • Issue

  • SUPPL. 1