Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.

Academic Article

Abstract

  • Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts. To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor) and TUG1 and WT1-AS (inferred onco-lncRNAs) dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells. Our analysis indicates that, although most lncRNAs are dysregulated in a tumor-specific manner, some, including OIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergistically dysregulate cancer pathways in multiple tumor contexts.
  • Published In

  • Cell Reports  Journal
  • Keywords

  • RNA-binding proteins, cancer gene, interactome, lncRNA, microRNA, modulation, noncoding RNA, pan-cancer, regulation
  • Digital Object Identifier (doi)

    Author List

  • Chiu H-S; Somvanshi S; Patel E; Chen T-W; Singh VP; Zorman B; Patil SL; Pan Y; Chatterjee SS; Cancer Genome Atlas Research Network
  • Start Page

  • 297
  • End Page

  • 312.e12
  • Volume

  • 23
  • Issue

  • 1