Impaired T lymphocyte function and differential cytokine response pattern in members from cancer families

Academic Article

Abstract

  • In an attempt to understand the basis of lowered natural killer (NK) and T cell functions in unaffected members from cancer families, we investigated cytotoxic T lymphocyte function (CD3-directed lysis) and the ability of the lymphocytes to respond to cytokines such as IL-2, IFN-α and IL-12. We observed lower CD3-mediated cytotoxic activity in these individuals supported by significantly lower numbers of circulating CD3+ lymphocytes. The cytokine treatment studies revealed impaired response to IFN-α and IL-12 in unaffected members and breast cancer patients. The observations presented herein not only reinforce our earlier finding that lower NK and T lymphocyte function may be a feature of cancer families, but also suggest that such impaired responses may be one of the factors contributing to lower cytotoxic potential of the circulating lymphocytes.
  • Authors

    Published In

  • Natural Immunity  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 14000860
  • Author List

  • Shevde LA; Joshi NN; Advani SH; Nadkarni JJ
  • Start Page

  • 146
  • End Page

  • 156
  • Volume

  • 16
  • Issue

  • 4