Everolimus in pulmonary transplantation: Pharmacokinetics and exposure-response relationships

Academic Article

Abstract

  • Background: In this study we evaluated exposure, safety and efficacy data from an international trial of everolimus. We sought to identify a tolerated and efficacious range for blood levels of this agent in maintenance lung transplant recipients. Methods: In a randomized, double-blind, multicenter trial, 213 maintenance lung transplant recipients received either everolimus 1.5 mg twice daily (n = 101) or azathioprine 1 to 3 mg/kg/day (n = 112) with cyclosporine and corticosteroids. At 15 visits over the first 2 years of the trial, we obtained 826 everolimus trough (C0) blood samples. We used median-effect analysis to assess relationships between everolimus C0 vs efficacy and safety responses. Results: Everolimus administration began at 1.5 mg twice daily and was progressively lowered over the first 2 months to an average of 1.2 ± 0.4 mg twice daily, which was maintained thereafter. This dose yielded median C0 levels of 6.6 ng/ml (10th to 90th percentiles: 2.8 to 11.8 ng/ml). Over this range of everolimus C0, freedom from a decline in pulmonary function with bronchiolitis obliterans syndrome and freedom from biopsy-proven acute rejection were both <88%. The incidence of increased cholesterol (>6.5 mmol/liter), increased triglycerides (>2.9 mmol/liter) and transiently decreased platelet count (<100 × 109/liter) rose significantly with increasing C0. Infections and drug-related adverse events were not significantly related to exposure. Conclusions: A tolerated and efficacious concentration range for everolimus in maintenance lung transplantation appears to be 3 to 12 ng/ml when used in conjunction with cyclosporine and corticosteroids. This range should be prospectively assessed with possible refinement as more clinical experience is gained. Copyright © 2006 by the International Society for Heart and Lung Transplantation.
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    Digital Object Identifier (doi)

    Author List

  • Kovarik JM; Snell GI; Valentine V; Aris R; Chan CKN; Schmidli H; Pirron U
  • Start Page

  • 440
  • End Page

  • 446
  • Volume

  • 25
  • Issue

  • 4