Frequent truncating mutations of STAG2 in bladder cancer

Academic Article


  • Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
  • Published In

  • Nature Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Solomon DA; Kim JS; Bondaruk J; Shariat SF; Wang ZF; Elkahloun AG; Ozawa T; Gerard J; Zhuang D; Zhang S
  • Start Page

  • 1428
  • End Page

  • 1430
  • Volume

  • 45
  • Issue

  • 12