Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma

Academic Article


  • We describe the role of increased eicosanoid production in inducing immunodepression associated with shock and trauma and the potential mechanisms by which prostaglandins produce immunosuppression. The effects of prefeeding with a diet high in n-3 polyunsaturated fatty acids (PUFAs) in preventing trauma-induced immunosuppression, and of such a diet on cellular immunity in patients after trauma are described. The potential mechanisms by which enteral diets containing n-3 PUFAs produce beneficial effects are also discussed. Although there is controversy concerning the immunomodulatory mechanisms of this diet, most of the information available indicates that dietary supplementation with n-3 PUFAs may prevent immunosuppression after trauma. Further studies are needed, however, to determine the precise composition and duration of supplementation with n-3 PUFAs that prevent the deleterious immune responses but do not alter normal immunoresponsiveness.
  • Authors

    Published In

  • Nutrition  Journal
  • Author List

  • Ayala A; Chaudry IH
  • Start Page

  • 1
  • End Page

  • 11
  • Volume

  • 11
  • Issue

  • 1