Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates.

Academic Article


  • Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.
  • Authors

    Published In


  • AGA, Appropriate for gestational age, BW, Birth weight, COL4A1, Collagen 4A1, Gr, Grade, IL, IVH, Interleukin, Intraventricular hemorrhage, MTHFR, Methylenetetrahydrofolate reductase, TNF, Tumor necrosis factor, Birth Weight, Case-Control Studies, Cerebral Hemorrhage, Female, Genetic Predisposition to Disease, Genotype, Humans, Infant, Newborn, Infant, Premature, Male, Methylenetetrahydrofolate Reductase (NADPH2), Steroids
  • Digital Object Identifier (doi)

    Author List

  • Adén U; Lin A; Carlo W; Leviton A; Murray JC; Hallman M; Lifton RP; Zhang H; Ment LR; Gene Targets for Intraventricular Hemorrhage Study Group
  • Start Page

  • 1503
  • End Page

  • 6.e1
  • Volume

  • 163
  • Issue

  • 5