Immune recognition of proteins: Conclusions, dilemmas and enigmas

Academic Article

Abstract

  • The immune system distinguishes between two types of antigenic sites: one of these binds to immunoglobulins (IgGs) (i.e. antibodies), while the other binds to receptor molecules on T lymphocytes (i.e. the T‐cell receptors (TcRs)). The latter interaction occurs only when the antigen is presented in association with a self‐transplantation antigen, a so‐called MHC‐restriction element. This article discusses what is known about the structure of antigenic sites and their molecular interactions with antibodies, MHC‐restriction elements, and T‐lymphocyte receptors. Copyright © 1987 Cambridge University Press
  • Authors

    Published In

  • BioEssays  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 17596253
  • Author List

  • Smith JA; Rose GD
  • Start Page

  • 112
  • End Page

  • 116
  • Volume

  • 6
  • Issue

  • 3