Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line

Academic Article


  • Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is 'active'; the other, 'silent' allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 x 10-4 per cell generation. This high rate is termed hypermutation.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Wabl M; Burrows PD; Von Gabain A; Steinberg C
  • Start Page

  • 479
  • End Page

  • 482
  • Volume

  • 82
  • Issue

  • 2