Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

Academic Article


  • Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.
  • Authors


  • Alleles, Animals, B-Lymphocytes, Cell Compartmentation, Codon, Gene Expression Regulation, Immunoglobulin Heavy Chains, Mathematics, Mice, Mice, Inbred BALB C, Multiple Myeloma, Mutation, Stem Cells
  • Author List

  • Wabl M; Burrows PD; von Gabain A; Steinberg C
  • Start Page

  • 479
  • End Page

  • 482
  • Volume

  • 82
  • Issue

  • 2