A Mott cell hybridoma.

Academic Article

Abstract

  • A hybridoma is described that exhibits all the characteristic features of Mott cells. It has spherules (Russell bodies) in the cytoplasm made up of dilated rough endoplasmatic reticulum and containing condensed immunoglobulin (lambda 1 light chains). Some of the cells appear to be very fragile, and free spherules are often found on cell smears. Cells with the Mott cell characteristics are still able to divide, but they do not secrete immunoglobulin. Hybridomas of this kind should be useful for determining the place of the Mott cell within the scheme of B cell differentiation.
  • Authors

    Published In

    Keywords

  • Animals, B-Lymphocytes, Cell Differentiation, Fluorescent Antibody Technique, Hybridomas, Immunoglobulin lambda-Chains, Mice, Microscopy, Electron, Plasma Cells
  • Digital Object Identifier (doi)

    Authorlist

  • Weiss S; Burrows PD; Meyer J; Wabl MR
  • Start Page

  • 744
  • End Page

  • 748
  • Volume

  • 14
  • Issue

  • 8