Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.

Academic Article

Abstract

  • Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.
  • Authors

    Published In

  • Nature  Journal
  • Keywords

  • Animals, B-Lymphocytes, Base Sequence, Cell Line, Gene Expression Regulation, Genes, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Immunoglobulin Variable Region, Immunoglobulin gamma-Chains, Immunoglobulin mu-Chains, Mice
  • Author List

  • Burrows PD; Beck-Engeser GB; Wabl MR
  • Start Page

  • 243
  • End Page

  • 246
  • Volume

  • 306
  • Issue

  • 5940