Anti-ischemic effects of amlodipine in patients with stable angina pectoris and myocardial ischemia during daily life. Amlodipine Study Group.

Academic Article

Abstract

  • Ambulatory electrocardiographic monitoring was used to assess the anti-ischemic effects of amlodipine in a subset of 56 patients enrolled in a 14-week withdrawal study; amlodipine therapy resulted in a marked decrease in the overall mean number of ischemic events and the average number of transient ischemic episodes (p <0.005). Amlodipine substantially reduced the number of ischemic events among all patients during the single-blind phase, with further significant reductions recorded among patients who remained on amlodipine during double-blind therapy, but the number of ischemic events increased almost to baseline levels in patients switched to placebo during double-blind therapy (p = 0.01 by analysis of variance).
  • Published In

    Keywords

  • Adolescent, Adult, Aged, Aged, 80 and over, Amlodipine, Angina Pectoris, Double-Blind Method, Electrocardiography, Ambulatory, Female, Humans, Male, Middle Aged, Myocardial Ischemia, Single-Blind Method
  • Pubmed Id

  • 9126950
  • Author List

  • Deedwania PC
  • Start Page

  • 1117
  • End Page

  • A9
  • Volume

  • 83
  • Issue

  • 7