Anti-ischemic effects of Amlodipine in patients with stable angina pectoris and myocardial ischemia during daily life

Academic Article

Abstract

  • Ambulatory electrocardiographic monitoring was used to assess the anti- ischemic effects of amlodipine in a subset of 56 patients enrolled in a 14- week withdrawal study; amlodipine therapy resulted in a marked decrease in the overall mean number of ischemic events and the average number of transient ischemic episodes (p <0.005). Amlodipine substantially reduced the number of ischemic events among all patients during the single-blind phase, with further significant reductions recorded among patients who remained on amlodipine during double-blind therapy, but the number of ischemic events increased almost to baseline levels in patients switched to placebo during double-blind therapy (p = 0.01 by analysis of variance).
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9126950
  • Author List

  • Deedwania PC; Allen J; Bittar N; Bouchard A; Brandon M; Bruns D; Carbajal E; Checton J; Corder C; Cutler N
  • Start Page

  • 1117
  • End Page

  • 1119
  • Volume

  • 83
  • Issue

  • 7