Laparoendoscopic single-site (LESS) surgery is a relatively novel surgical approach, minimizing the incisions used for laparoendoscopic access. Since its development, LESS has been reported for a multitude of urologic procedures. The largest experience of urologic LESS surgery falls within the realm of upper tract surgeries, including extirpative, reconstructive, and ablative operations. Herein, we describe the experience with LESS for upper tract urologic surgery, including simple nephrectomy, radical nephrectomy, partial nephrectomy, nephroureterectomy, donor nephrectomy, adrenalectomy, pyeloplasty, renal cryoablation, and renal cyst decortications. In addition to a comprehensive evaluation of the various upper tract urologic LESS surgical procedures, the pertinent history, technical aspects specific to successful implementation, and future directions of the field are reported and explored in detail. Specific attention is given to the different trocar placements reported and characteristics of the access platforms used. © 2012 Blackwell Publishing Ltd.