Molecular epidemiology of tuberculosis in a sentinel surveillance population

Academic Article


  • We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11,923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ellis BA; Crawford JT; Braden CR; McNabb SJN; Moore M; Kammerer S; Bates J; Benjamin W; Bifani P; Cave MD
  • Start Page

  • 1197
  • End Page

  • 1209
  • Volume

  • 8
  • Issue

  • 11