Molecular epidemiology of tuberculosis in a sentinel surveillance population.

Academic Article


  • We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
  • Published In


  • Adolescent, Adult, Aged, Antitubercular Agents, Child, Child, Preschool, Cluster Analysis, Continental Population Groups, DNA, Bacterial, Drug Resistance, Multiple, Bacterial, Female, Genotype, Humans, Infant, Longitudinal Studies, Male, Middle Aged, Molecular Epidemiology, Mycobacterium tuberculosis, Polymorphism, Restriction Fragment Length, Risk Factors, Sentinel Surveillance, Time Factors, Tuberculosis, United States
  • Digital Object Identifier (doi)

    Author List

  • Ellis BA; Crawford JT; Braden CR; McNabb SJN; Moore M; Kammerer S; National Tuberculosis Genotyping and Surveillance Network Work Group
  • Start Page

  • 1197
  • End Page

  • 1209
  • Volume

  • 8
  • Issue

  • 11