Durability of response to treatment among antiretroviral-experienced subjects: 48-week results from AIDS Clinical Trials Group Protocol 359.

Academic Article


  • The 24-week extension of AIDS Clinical Trials Group Protocol 359, a study of human immunodeficiency virus (HIV)-infected, indinavir-experienced patients, was designed to study the durability of "salvage" treatment regimens. Patients received saquinavir in combination with either ritonavir or nelfinavir and, in addition, delavirdine, adefovir, or both. Patients who demonstrated a virologic response at weeks 12-16 were eligible to continue therapy in the extension through week 48. Of the 105 eligible subjects who were enrolled in the extension, 86 (82%) completed 48 weeks, and 49 (57%) of those 86 had HIV RNA levels
  • Published In


  • Antiviral Agents, CD4 Lymphocyte Count, Delavirdine, Double-Blind Method, Drug Therapy, Combination, HIV, HIV Infections, HIV Protease Inhibitors, Humans, Prospective Studies, RNA, Viral, Reverse Transcriptase Inhibitors, Ritonavir, Salvage Therapy, Saquinavir
  • Digital Object Identifier (doi)

    Author List

  • Gulick RM; Hu XJ; Fiscus SA; Fletcher CV; Haubrich R; Cheng H; Acosta E; Lagakos SW; Swanstrom R; Freimuth W
  • Start Page

  • 626
  • End Page

  • 633
  • Volume

  • 186
  • Issue

  • 5