Mortality under plausible interventions on antiretroviral treatment and depression in HIV-infected women: an application of the parametric g-formula.

Academic Article

Abstract

  • PURPOSE: Among HIV-infected persons, antiretroviral therapy (ART) and depression are strongly associated with mortality. We estimated reductions in 5-year mortality in Women's Interagency HIV Study participants under plausible hypothetical increases in ART initiation and reductions in depression (CES-D score≥16). METHODS: We followed 885 ART-naïve Women's Interagency HIV Study participants for 5 years from their first study visit after April 1998 to death or censoring. We used the parametric extended g-formula to estimate cumulative mortality under the natural course (NC) and alternative exposure distributions. RESULTS: Baseline prevalence of depression was 52% and 62% initiated ART by 5 years. Compared with mortality under NC (13.2%), immediate ART and elimination of 36% or 67% of depressive episodes were associated with risk differences (RDs) of -5.2% (95% CI: -7.7%, -2.6%) and -5.7 (95% CI: -8.7, -2.7). Compared with immediate ART and NC for depression, additionally eliminating 67% of the depressive episodes was associated with RD = -1.6 (95% CI: -3.9, 0.8). Compared with 5-year mortality under NC for ART and elimination of 67% of depression, also initiating ART immediately was associated with RD = -2.6 (95% CI: -5.0, -0.3). CONCLUSIONS: Increasing ART initiation and reducing depression were associated with moderate reductions in 5-year mortality among HIV-infected women.
  • Published In

    Keywords

  • Antiretroviral therapy, Cohort studies, Depression, HIV, Mortality, Survival analysis, Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Depression, Female, HIV Infections, Humans, Middle Aged, Prevalence, Risk Factors, Survival Analysis, United States
  • Digital Object Identifier (doi)

    Author List

  • Lesko CR; Todd JV; Cole SR; Edmonds A; Pence BW; Edwards JK; Mack WJ; Bacchetti P; Rubtsova A; Gange SJ
  • Start Page

  • 783
  • End Page

  • 789.e2
  • Volume

  • 27
  • Issue

  • 12