Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide

Academic Article

Abstract

  • Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus. Here we demonstrate that these mice have a defect in antigen-stimulated suicide of activated T cells in mature CD4+ and CD8+ T cell compartments. The defective suicide pathway is evident when the T cells are stimulated with antigen on antigen-presenting cells or with immobilized anti-CD3 in the absence of antigen-presenting cells. These studies, in concert with the work of others, suggest that antigen-stimulated death of mature cells may be important both in establishing peripheral tolerance and in limiting inflammation during normal immune responses.
  • Digital Object Identifier (doi)

    Author List

  • Russell JH; Rush B; Weaver C; Wang R
  • Start Page

  • 4409
  • End Page

  • 4413
  • Volume

  • 90
  • Issue

  • 10