A Simple, Cost-Effective Screening Protocol to Rule Out Periprosthetic Infection

Academic Article


  • The differential diagnosis of pain after total knee arthroplasty includes infection. Effective screening tools should have high sensitivity and are cost-effective. We evaluated 296 patients who underwent total knee revision at our institution. One hundred sixteen patients (39%) were classified as infected and 180 patients (61%) were considered noninfected. The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of the infected patients were 85 mm/h and 110 mg/L, respectively. The mean ESR and CRP of the noninfected patients were 22 mm/h and 7 mg/L, respectively. Five patients (4%) in the infected group had both normal ESR and CRP. Infection was suspected in all 5 patients, and an organism was cultured in 4 of the 5 cases. Erythrocyte sedimentation rate and CRP, when used in combination, serve as a useful screening tool in patients with a painful total knee arthroplasty. © 2008 Elsevier Inc. All rights reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Austin MS; Ghanem E; Joshi A; Lindsay A; Parvizi J
  • Start Page

  • 65
  • End Page

  • 68
  • Volume

  • 23
  • Issue

  • 1