This article describes the effect of resources and Stressors on 156 family members who provided care and support for an HIV-infected woman. Both resources and Stressors were related to the family members' perceived burden and depressive mood, and resources did little to buffer the associations between stress and burden and between stress and depression. Together, resources and Stressors accounted for 50% of the variance in family members' perceived burden and 21% of the variance in their depressive mood. The only variable important in predicting both burden and depressive mood was the family member's feelings of stigma. These results suggest that efforts should be made to reduce the stigma felt by family members and to help them obtain additional family and community resources to ameliorate the burden of caregiving.