A Case Report of Pregnancy During Use of Targeted Therapeutics for Cystic Fibrosis.

Academic Article

Abstract

  • New therapeutics, such as ivacaftor, and the combination drug lumacaftor/ivacaftor that target the underlying genetic cause of cystic fibrosis are being hailed as game-changers in this era of personalized medicine. Although these drugs improve lung function, their effects on female fertility have not been studied. In this case report we describe one woman's experience with ivacaftor and her unanticipated pregnancy. Implications related to comprehensive sexual and reproductive health care for women with cystic fibrosis are presented.
  • Keywords

  • cystic fibrosis, fertility, ivacaftor, lumacaftor/ivacaftor, sexual and reproductive health, Adult, Aminophenols, Aminopyridines, Benzodioxoles, Cystic Fibrosis, Dose-Response Relationship, Drug, Drug Combinations, Female, Humans, Precision Medicine, Pregnancy, Pregnancy Complications, Quinolones
  • Digital Object Identifier (doi)

    Authorlist

  • Ladores S; Kazmerski TM; Rowe SM
  • Start Page

  • 72
  • End Page

  • 77
  • Volume

  • 46
  • Issue

  • 1