In patients who underwent revision TKA from 1993 to 2005 and responded to follow-up questionnaires 2 or 5 years postrevision TKA, we studied whether body mass index (BMI), comorbidity (measured by validated Deyo-Charlson index), sex, and age predict activity limitation 2 and 5 years after revision TKA. Overall moderate-severe activity limitation was defined as 2 or more activities (walking, stairs, rising chair) with moderate-severe limitation. Multivariable logistic regressions also adjusted for income, diagnosis, and distance from medical center and American Society of Anesthesiologists physical status score. The prevalence of overall moderate-severe activity limitation was high: 46.5% (677/1456) at 2 years and 50.5% (420/832) at 5 years postrevision TKA. At both 2 and 5 years of follow-up, BMI of 40 or higher, higher Deyo-Charlson score, female sex, and age greater than 80 years, each significantly predicted higher odds of moderate-severe overall activity limitation. © 2010.