C2

Chapter

Abstract

  • © Elsevier Ltd All rights reserved. The second complement component C2 is a multidomain serine protease that provides catalytic activity to the C3 and C5 convertases of classical and lectin pathways of complement. Formation of these convertases requires the Mg-dependent binding of C2 to C4b and subsequent cleavage of C2 by C1s or mannose-binding lectin-associated serine protease 2, respectively.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9780128104200
  • Start Page

  • 127
  • End Page

  • 134