A Sprayable Hyaluronate/Carboxymethylcellulose Adhesion Barrier Exhibits Regional Adhesion Reduction Efficacy and Does Not Impair Intestinal Healing

Academic Article

Abstract

  • Background: While bioresorbable solid barriers such as Seprafilm® prevent adhesions, their efficacy is limited to sites of application. The aim of this study was to assess the effectiveness of the sprayable adhesion barrier Sepraspray® in preventing adhesions to sites of direct application and to remote sites. Methods: Intraabdominal adhesions were induced in 30 rats by creating three ischemic buttons on each side of a midline incision. To assess efficacy, Sepraspray (5 mg/button) or Seprafilm (1 cm 2/button) was applied over three buttons on one side of the peritoneum. Operated control animals received no treatment. On day 7, adhesions were scored as percent of buttons with adhesions. To assess safety, 81 rats underwent a colonic transection repaired with an end-to-end anastomosis. Both barriers were applied circumferentially to anastomoses. Controls received no product. The integrity of healing anastomosed colonic wounds was assessed by burst pressure and tensile strength at days 3, 5, and 7 postoperatively. Results: The direct application of both Sepraspray and Seprafilm significantly (p < 0.001) reduced adhesion formation compared to controls. While Seprafilm had no remote effect on adhesion formation, Sepraspray significantly (p < 0.001) reduced adhesion formation to contralateral ischemic buttons. Neither barrier affected anastomotic integrity at any time point. Conclusions: Sepraspray has widespread efficacy throughout the peritoneum in reducing adhesions without compromising intestinal healing. Furthermore, this sprayable alternative offers the potential for easier intraabdominal application. © 2011 The Society for Surgery of the Alimentary Tract.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 3178926
  • Author List

  • Sheldon HK; Gainsbury ML; Cassidy MR; Chu DI; Stucchi AF; Becker JM
  • Start Page

  • 325
  • End Page

  • 333
  • Volume

  • 16
  • Issue

  • 2