NF-κB and STAT3 in glioblastoma: Therapeutic targets coming of age

Academic Article

Abstract

  • © Informa UK, Ltd. Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-κB and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-κB and STAT3 signaling, the ways in which these pathways contribute to GBM and advances in preclinical and clinical targeting of these two signaling cascades.
  • Digital Object Identifier (doi)

    Author List

  • Gray GK; McFarland BC; Nozell SE; Benveniste EN
  • Start Page

  • 1293
  • End Page

  • 1306
  • Volume

  • 14
  • Issue

  • 11