This article is a retrospective review of a patient resource library in a busy urban outpatient clinic, which resulted from a unique collaboration among the clinic administration, a comprehensive cancer center, and an academic health sciences library. During the first five years, the library has seen 27,134 visitors and answered 7,635 information requests. Internet resources were used in more than 50% of the transactions, followed by print brochures (34%). The results of a three-year Institutional Review Board-approved study analyzing information requests are presented. Ongoing experiences and future initiatives that support the clinic's mission and patient satisfaction are also discussed. © 2013 Copyright Lee A. Vucovich, Tracy E. Powell and Cara L. Wilhelm.