Association of dietary sodium and potassium intakes with albuminuria in normal-weight, overweight, and obese participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

Academic Article

Abstract

  • BACKGROUND: Among obese adults, sodium intake has been associated with cardiovascular disease. Few data are available on sodium intake and albuminuria, a marker of kidney damage and risk factor for cardiovascular disease. OBJECTIVE: We examined the relation between dietary sodium and potassium intakes and the ratio of sodium to potassium (Na/K) with albuminuria by BMI in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study (n = 30,239 adults aged ≥45 y). DESIGN: A modified Block 98 food-frequency questionnaire was used for dietary assessment in 21,636 participants, and nutritional variables were categorized by sex-specific quintiles. Normal weight, overweight, and obese were defined as BMI (in kg/m(2)) categories of 18.5-24.9, 25-29.9, and ≥30, respectively. Albuminuria was defined as a ratio (mg/g) of urinary albumin to creatinine of ≥30. RESULTS: The prevalences of albuminuria were 11.5%, 11.6%, and 16.0% in normal-weight, overweight, and obese participants, respectively. The multivariable-adjusted ORs for albuminuria in a comparison of the highest with the lowest quintile of Na/K intake (≥1.12 to <0.70 for men and ≥1.07 to <0.62 for women) were 0.89 (95% CI: 0.65, 1.22), 1.08 (95% CI: 0.85, 1.36), and 1.28 (95% CI: 1.02, 1.61) in normal-weight, overweight, and obese participants, respectively. The highest quintile of dietary sodium was associated with an increased OR for albuminuria in obese participants (OR: 1.44; 95% CI: 1.00, 2.07) but not in normal-weight or overweight participants. Dietary potassium was not associated with albuminuria. CONCLUSION: In obese adults, higher dietary Na/K and sodium intakes were associated with albuminuria.
  • Keywords

  • Aged, Aged, 80 and over, Albuminuria, Body Mass Index, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Obesity, Overweight, Potassium Deficiency, Potassium, Dietary, Prevalence, Renal Insufficiency, Risk Factors, Sodium, Dietary, Southeastern United States, Surveys and Questionnaires
  • Digital Object Identifier (doi)

    Author List

  • Aaron KJ; Campbell RC; Judd SE; Sanders PW; Muntner P
  • Start Page

  • 1071
  • End Page

  • 1078
  • Volume

  • 94
  • Issue

  • 4