Self-Report Measures in the Assessment of Antiretroviral Medication Adherence: Comparison with Medication Possession Ratio and HIV Viral Load.

Academic Article

Abstract

  • BACKGROUND: Adherence is a major determinant of the effectiveness of antiretroviral therapy (ART). We determined the association between self-reported adherence (SRA) and medication possession ratio (MPR), a pharmacy-based adherence measure, and their respective associations with viral load. METHODS: Adherence to ART was assessed by MPR over 6 months and by self-report which included a question with a Likert-type scale response, a visual analogue scale (VAS), and an inquiry about the last time the patients skipped any prescribed medications. RESULTS: Taking MPR as the "gold standard," all 3 SRA measures displayed high specificity but low sensitivity. The prevalence ratio (95% confidence interval) for viral load ≥50 copies/mL was 2.19 (1.07-4.50) for MPR <90%, 1.98 (1.04-3.78) for poor/fair/good versus excellent/very good ability to take antiretroviral drugs, 1.47 (0.79-2.75) for skipping medications within the past 2 weeks, and 2.51 (1.39-4.53) for VAS <95%. CONCLUSION: These data suggest various SRA measures hold clinical value in screening for poor ART adherence.
  • Keywords

  • HIV, adherence, antiretroviral therapy, medication possession ratio, Adult, Anti-HIV Agents, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Male, Medication Adherence, Middle Aged, Self Report, Viral Load
  • Digital Object Identifier (doi)

    Author List

  • Kabore L; Muntner P; Chamot E; Zinski A; Burkholder G; Mugavero MJ
  • Start Page

  • 156
  • End Page

  • 162
  • Volume

  • 14
  • Issue

  • 2