Use of acetazolamide as an adjunct to carbamazepine in refractory partial seizures.

Academic Article


  • Acetazolamide (Diamox) (AZM) was evaluated as an adjunct to carbamazepine (CBZ) monotherapy in 48 refractory partial seizure patients at a tertiary care referral center. Patient ages ranged from 6 to 64 years (average 28 years). Seizure frequencies for the pre-AZM baseline period (CBZ monotherapy) were compared with the seizure frequencies at different daily doses of AZM. Patients with a 50% decrease in seizure frequency were considered responders. Twenty-one patients were responders (44%) and three became completely seizure-free. Effective doses ranged from 3.8 to 22.0 mg/kg/day. Effective plasma concentrations ranged from 1 to 22 micrograms/ml in selected patients. Durations of response time to AZM ranged from 3 to 30 months (average 12.9 months). Three patients lost response, one temporarily. Side effects were seen in 10 patients, requiring discontinuation in three.
  • Authors

    Published In

  • Epilepsia  Journal
  • Keywords

  • Acetazolamide, Adolescent, Adult, Carbamazepine, Child, Drug Therapy, Combination, Epilepsies, Partial, Humans, Middle Aged, Osmolar Concentration
  • Author List

  • Oles KS; Penry JK; Cole DL; Howard G
  • Start Page

  • 74
  • End Page

  • 78
  • Volume

  • 30
  • Issue

  • 1