Objective: The authors sought to determine the association between physical inactivity (characterized by exercise and television watching levels) and long-term rates of community-acquired sepsis. Methods: The study utilized a population-based cohort of 30,183 adult (> 45 years) community dwelling adults. Subjects reported weekly exercise (low = none, medium = 1-3. times/week, high = > 4. times/week) and daily television watching (low = < 1. h/day, medium = 1-3. h/day, high = > 4. h/day) levels. The authors evaluated the association between exercise, television watching and rates of sepsis, defined as hospital treatment for a serious infection with > 2 Systemic Inflammatory Response Syndrome (SIRS) criteria. Results: Among 30,183 participants, 1500 experienced a sepsis event. Reported weekly exercise was: high 8798 (29.2%), medium 10,695 (35.4%), and low 10,240 (33.9%). Where available, reported daily television watching was: low 4615 (19.6%), medium 11,587 (49.3%) and high 7317 (31.1%). Decreased weekly exercise was associated with increased adjusted sepsis rates (high - referent; medium - HR 1.02, 95% CI 0.96-1.20; low - 1.33, 1.13-1.56). Daily television watching was not associated with sepsis rates. Sepsis rates were highest among those with both low exercise and high television watching levels (HR 1.49, 95% CI: 1.10-2.01). Conclusions: Physical inactivity may be associated with increased long-term rates of community-acquired sepsis. © 2014 Elsevier Inc.