Physical inactivity and long-term rates of community-acquired sepsis.

Academic Article


  • OBJECTIVE: The authors sought to determine the association between physical inactivity (characterized by exercise and television watching levels) and long-term rates of community-acquired sepsis. METHODS: The study utilized a population-based cohort of 30,183 adult (≥45 years) community dwelling adults. Subjects reported weekly exercise (low=none, medium=1-3times/week, high=≥4times/week) and daily television watching (low=<1h/day, medium=1-3h/day, high=≥4h/day) levels. The authors evaluated the association between exercise, television watching and rates of sepsis, defined as hospital treatment for a serious infection with ≥2 Systemic Inflammatory Response Syndrome (SIRS) criteria. RESULTS: Among 30,183 participants, 1500 experienced a sepsis event. Reported weekly exercise was: high 8798 (29.2%), medium 10,695 (35.4%), and low 10,240 (33.9%). Where available, reported daily television watching was: low 4615 (19.6%), medium 11,587 (49.3%) and high 7317 (31.1%). Decreased weekly exercise was associated with increased adjusted sepsis rates (high - referent; medium - HR 1.02, 95% CI 0.96-1.20; low - 1.33, 1.13-1.56). Daily television watching was not associated with sepsis rates. Sepsis rates were highest among those with both low exercise and high television watching levels (HR 1.49, 95% CI: 1.10-2.01). CONCLUSIONS: Physical inactivity may be associated with increased long-term rates of community-acquired sepsis.
  • Published In


  • Diet, Epidemiology, Exercise, Infections, Physical activity, Sedentary behavior, Sepsis, Aged, Aged, 80 and over, Cohort Studies, Community-Acquired Infections, Female, Humans, Immune System, Male, Middle Aged, Motor Activity, Population Surveillance, Sedentary Behavior, Sepsis, United States
  • Digital Object Identifier (doi)

    Author List

  • Wang HE; Baddley J; Griffin RL; Judd S; Howard G; Donnelly JP; Safford MM
  • Start Page

  • 58
  • End Page

  • 64
  • Volume

  • 65