The role of plasma lipids in carotid bifurcation atherosclerosis

Academic Article


  • The severity of coronary artery atherosclerosis correlates with increased plasma concentrations of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and triglycerides and with decreased plasma concentrations of high‐density lipoprotein cholestrol (HDL‐C). The role of plasma lipoproteins in the pathogenesis of cerebral atherosclerosis, however, is less clear. Several investigators report that lipoprotein abnormlities correlate inversely with the incidence of cerebral infarction. We analyzed risk factors for carotid bifurcation atheroscerosis in 121 consecutive patients who underwent cerebral angiography. This analysis revealed a significant positive correlation between the plasma TC/HDL‐C ratio and the extent of carotid bifurcation atherosclerosis (p = 0.01). The extent of atherosclerosis correlated inversely with plasma concentrations of HDL‐C (p = 0.02). Triglyceride concentration correlated positively with the extent of atherosclerosis with marginal significance (p = 0.07). LDL‐C and TC concentrations did not correlate with bifurcation atherosclerosis (p > 0.1). Only 4% of the variation in the extent of bifurcation atherosclerosis was explicable on the basis of plasma lipoprotien concentrations. Copyright © 1985 the American Neurological Association
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Ford CS; Crouse JR; Howard G; Toole JF; Ball MR; Frye J
  • Start Page

  • 301
  • End Page

  • 303
  • Volume

  • 17
  • Issue

  • 3