Prehypertension, racial prevalence and its association with risk factors: Analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

Academic Article


  • BACKGROUND: There are few available data on the epidemiology of prehypertension (preHTN). To determine racial, clinical, and demographic differences in the prevalence of preHTN and its cross-sectional association with vascular risk factors. METHODS: Cross-sectional analysis of 5,553 prehypertensives, 20,351 hypertensive's, and 4,246 nonhypertensive participants (age ≥45), from a population-based national cohort study (REasons for Geographic And Racial Differences in Stroke (REGARDS) total population 30,239, of whom 30,150 had adequate blood pressure (BP) measurements) enrolled from January 2003-October 2007 with oversampling from the southeastern stroke belt, and black individuals. Baseline data were collected using a combination of telephone interview and in-home evaluation. preHTN was defined according to The Seventh Report of the Joint national Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines. RESULTS: The prevalence of preHTN was associated with age and black race (62.9% in blacks compared to 54.1% in whites). A higher prevalence of preHTN was observed in obese individuals, self-reported heart disease; and, those with elevated high-sensitivity C reactive protein (hsCRP), diabetes, and microalbuminuria compared to those without these factors. Heavy alcohol consumption in white participants was associated with increased odds of preHTN (odds ratio (OR) = 1.32) but was even greater in black participants (OR = 2.27). CONCLUSION: The prevalence of preHTN increased by age and African-American race. In addition, a higher prevalence of preHTN was observed with elevated hsCRP, diabetes, microalbuminuria, and those with heavy alcohol consumption compared to those without these factors.
  • Published In


  • African Americans, Aged, Blood Pressure, Chi-Square Distribution, Cross-Sectional Studies, European Continental Ancestry Group, Female, Health Status Disparities, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Prehypertension, Prevalence, Residence Characteristics, Risk Assessment, Risk Factors, Stroke, United States
  • Digital Object Identifier (doi)

    Author List

  • Glasser SP; Judd S; Basile J; Lackland D; Halanych J; Cushman M; Prineas R; Howard V; Howard G
  • Start Page

  • 194
  • End Page

  • 199
  • Volume

  • 24
  • Issue

  • 2