Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection.

Academic Article

Abstract

  • OBJECTIVE: We evaluated time to clearance of high risk (HR) HPV infection in relation to functional variants in three genes (CYP1A1, GSTT1, and GSTM1). METHODS: The study group consisted of 450 HR-HPV infected women from the Atypical squamous cells of undetermined significance-low-grade squamous intraepithelial Lesion Triage Study (ALTS) cohort followed up at the clinical center at Birmingham, Alabama. The Cox proportional hazard model with the Wei-Lin-Weisfeld (WLW) approach was used, controlling for relevant covariates. RESULTS: Women who were polymorphic for CYP1A1 experienced an HR-HPV clearance rate that was 20% (HR=0.80, p=0.04) lower than women without the polymorphism for CYP1A1, adjusting for all other cofactors. The GSTM1 null genotype was associated with higher HR-HPV clearance rate (HR=1.39, p=0.006). The polymorphism in GSTT1 was not significantly associated with time to clearance of HR-HPV. CONCLUSIONS: Xenobiotic metabolism genes may influence the natural history of HR-HPV infection and its progression to cervical cancer.
  • Published In

    Keywords

  • ALTS, CYP1A1, GSTM1, GSTT1, Host genetics, Adult, Cohort Studies, Cytochrome P-450 CYP1A1, DNA, Viral, Female, Genotype, Glutathione Transferase, Humans, Papillomaviridae, Papillomavirus Infections, Uterine Cervical Diseases, Uterine Cervical Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Sudenga SL; Shrestha S; Macaluso M; Partridge EE; Johanning GL; Piyathilake CJ
  • Start Page

  • 560
  • End Page

  • 564
  • Volume

  • 135
  • Issue

  • 3