Implications of Look AHEAD for clinical trials and clinical practice.

Academic Article


  • Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.
  • Published In


  • cardiovascular disease, dietary intervention, type 2 diabetes, Aged, Biomarkers, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Monitoring, Physiologic, Obesity, Overweight, Patient Education as Topic, Research Design, Risk Reduction Behavior, Surveys and Questionnaires, Time Factors, Triglycerides, United States, Weight Loss
  • Digital Object Identifier (doi)

    Author List

  • Wing RR; Look AHEAD Research Group
  • Start Page

  • 1183
  • End Page

  • 1191
  • Volume

  • 16
  • Issue

  • 12