Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway.

Academic Article

Abstract

  • Arsenic trioxide (As2O3) can induce apoptosis in many tumors. However, the associated mechanisms are not clearly understood. We found that As2O3 significantly inhibited the proliferation of WSU-CLL cells and induced apoptosis in dose- and time-dependent manners. WSU-CLL cells treated with 2μM As2O3 showed survivin down-regulation and p53 up-regulation. Survivin siRNA combined with As2O3 further inhibited the proliferation of WSU-CLL cells. p53 inhibition by siRNA prevented the down-regulation of survivin by As2O3 and prevented the As2O3-induced cytotoxicity of WSU-CLL cells. These results suggest that As2O3 may be of therapeutic value for chronic lymphocytic leukemia.
  • Authors

    Published In

  • Leukemia Research  Journal
  • Keywords

  • Apoptosis, Arsenic trioxide, P53 and CLL, Survivin, WSU-CLL, Antineoplastic Agents, Apoptosis, Arsenic Trioxide, Arsenicals, Cell Line, Tumor, Cell Survival, Down-Regulation, Gene Expression Regulation, Leukemic, Humans, Inhibitor of Apoptosis Proteins, Leukemia, Lymphocytic, Chronic, B-Cell, Oxides, Signal Transduction, Survivin, Tumor Suppressor Protein p53, Up-Regulation
  • Digital Object Identifier (doi)

    Author List

  • Zhang X-H; Feng R; Lv M; Jiang Q; Zhu H-H; Qing Y-Z; Bao J-L; Huang X-J; Zheng XL
  • Start Page

  • 1719
  • End Page

  • 1725
  • Volume

  • 37
  • Issue

  • 12