Comparison of class I‐ and II‐restricted T cell recognition of the identical peptide

Academic Article


  • There is structural and functional evidence that both class I‐ and II‐restricted T cells recognize short processed peptides bound to MHC molecules. Although the structural conformation of bound peptides remains unknown, no evidence of distinct structural motifs of class I‐ or class II‐restricted peptides has been described. Conversely, two algorithims proprosed to predict T cell epitopes, and based on primary amino acid sequence or tertiary structure, are both compatible with many observed class I‐ and class II‐restricted peptides. We previously identified eight class I‐restricted peptides which were also recognized by class II‐restricted T cells. Based on functional and direct binding studies, additional examples of peptides with both class I and II restrictions have been identified. In this study, we have directly compared the fine specificity of T cell recognition of a single epitope in a single mouse strain in the context of both class I‐ and class II‐restricted responses. Based on a panel of analogue peptides with amino acid substitutions and peptides of various lengths, we observed several striking similarities in the recognition patterns of both class I‐ and class II‐ restricted T cells. In addition, some characteristics of recognition were different in the two systems indicating that the recognition processes were similar but not identical. Copyright © 1991 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Perkins DL; Berriz G; Wang Y; Smith JA; Gefter ML
  • Start Page

  • 2781
  • End Page

  • 2789
  • Volume

  • 21
  • Issue

  • 11