The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix - loop - helix protein

Academic Article

Abstract

  • We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.
  • Published In

  • EMBO Journal  Journal
  • Author List

  • Chen Q; Cheng JT; Tsai LH; Schneider N; Buchanan G; Carroll A; Crist W; Ozanne B; Siciliano MJ; Baer R
  • Start Page

  • 415
  • End Page

  • 424
  • Volume

  • 9
  • Issue

  • 2