Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.

Academic Article

Abstract

  • Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) study is a 4-year randomized clinical trial of 693 overweight/obese women aged ≥21years diagnosed with any early stage breast cancer (stages I[≥1cm]-III) within the previous five years, designed to demonstrate the feasibility of achieving sustained weight loss and to examine the impact of weight loss on quality of life and co-morbidities, and to enable future exploration of biochemical mechanisms linking obesity to lower likelihood of disease-free survival. This trial is strategically designed as a vanguard for a fully-powered trial of women who will be evaluated for breast cancer recurrence and disease-free survival. Participants were recruited between 2010 and 2012 at four sites, had completed initial therapies, and had a body mass index between 25 and 45kg/m(2). The intervention featured a group-based cognitive-behavioral weight loss program with telephone counseling and tailored newsletters to support initial weight loss and subsequent maintenance, with the goal of 7% weight loss at two years. This study has high potential to have a major impact on clinical management and outcomes after a breast cancer diagnosis. This trial initiates the effort to establish weight loss support for overweight or obese breast cancer survivors as a new standard of clinical care.
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    Keywords

  • Aged, Body Mass Index, Breast Neoplasms, Cognitive Behavioral Therapy, Comorbidity, Diet, Reducing, Disease-Free Survival, Exercise Therapy, Female, Humans, Longitudinal Studies, Middle Aged, Neoplasm Recurrence, Local, Obesity, Overweight, Psychotherapy, Group, Quality of Life, Treatment Outcome, Weight Loss, Weight Reduction Programs
  • Digital Object Identifier (doi)

    Author List

  • Rock CL; Byers TE; Colditz GA; Demark-Wahnefried W; Ganz PA; Wolin KY; Elias A; Krontiras H; Liu J; Naughton M
  • Start Page

  • 282
  • End Page

  • 295
  • Volume

  • 34
  • Issue

  • 2