Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS.

Academic Article


  • OBJECTIVE: To determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration. METHODS: In a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40% energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase. RESULTS: Participants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p<0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (-7.1%, -4.6%, and -11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p<0.05) during the SMT. CONCLUSIONS: In women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.
  • Published In

  • Metabolism  Journal
  • Keywords

  • Intra-abdominal adipose tissue, Macronutrient composition, Obesity, Adipose Tissue, Adult, Body Composition, Cross-Over Studies, Diet, Reducing, Dietary Carbohydrates, Female, Humans, Insulin, Polycystic Ovary Syndrome, Postprandial Period
  • Digital Object Identifier (doi)

    Author List

  • Goss AM; Chandler-Laney PC; Ovalle F; Goree LL; Azziz R; Desmond RA; Wright Bates G; Gower BA
  • Start Page

  • 1257
  • End Page

  • 1264
  • Volume

  • 63
  • Issue

  • 10