A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids

Academic Article


  • Bispyrroloquinone and bispyrroloiminoquinone are two important polycyclic ring systems present in biologically active marine alkaloids such as Zyzzyanones, tsitsikammamines, and wakayin. A facile synthesis of these two ring systems starting from a 6-benzylamino indole-4,7-quinone or 6-benzylamino pyrroloiminoquinone is described here. This chemistry involves the construction of a pyrrole ring in a single step by treatment of the starting reagents with ethyl acetoacetate or phenylbutane-1,3-dione in the presence of ceric ammonium nitrate in MeOH/CH2Cl2 solvent. © 2009 Elsevier Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Murugesan S; Nadkarni DH; Velu SE
  • Start Page

  • 3074
  • End Page

  • 3076
  • Volume

  • 50
  • Issue

  • 25