Design, synthesis and activity of thio-linked arabinofuranosyl disaccharides against mycobacterial tuberculosis (MTB) and Mycobacterium avium complex (MAC)

Academic Article


  • We report the chemical synthesis of a series of disaccharides of arabinofuranose with a glycosidic sulfur linker as mimics of the acceptor for arabinofuranosyltransferases with and without using any activator to avoid any complex reactions. These analogs were tested for in vitro activity against MTB strain H37Ra and 3 MAC clinical isolates. MICs were determined using a colorimetric microdilution broth assay. Bactericidal activity was studied with kill curves over a period of seven days. Intracellular activity against MTB H37Ra was determined in the Mono Mac 6 (MM6) human monocytic cell line. ¬©ARKAT-USA, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Khare NK; Duarte FJ; Reynolds RC; Maddry JA
  • Start Page

  • 290
  • End Page

  • 315
  • Volume

  • 2013
  • Issue

  • 2