Background: Some retinoid X receptor (RXR) agonists have potential as cancer drugs. Results: Structures of RXR in complex with two different agonists show similar folds. Dynamics analysis reveals unique ligand-induced dynamics in helices 3, 11, and 12. Conclusion: Two networks of interactions that connect RXR agonists to coactivator binding are defined. © 2014 by the American Society for Biochemistry and Molecular Biology, Inc. .