Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease

Academic Article


  • In patients undergoing surgical resection of a metastatic brain tumor, whole brain radiation therapy reduces the risk of recurrence and neurologic death. Focal radiation has the potential to mitigate neurocognitive side effects. We present an institutional experience of postoperative radiosurgery for the treatment of brain metastases. A retrospective review of a prospectively maintained institutional radiosurgery database was performed for the years 2005–2015 identifying all adult patients treated with postoperative radiosurgery to the tumor bed. Primary endpoints include local recurrence and postoperative LMD. Kaplan-Meier curves and Cox regression were used to evaluate time to local recurrence and postoperative LMD. Ninety-one patients received adjuvant focal radiation for a brain metastasis. Median radiographic follow-up among patients who had not developed a local failure was 9 months. Of the 91 patients, 20 (22%) developed local recurrence and 32 (35%) experienced postoperative LMD. Freedom from local recurrence and LMD at 1 year was 84% and 69%, respectively. In multivariable models, predictors of local failure included the presence of more than one brain metastasis (HR = 2.65, p =.04) with a preoperative tumor diameter of >3 cm (HR = 4.16, p =.06) trending toward significance. There was a trend to a higher risk of LMD with >1 tumor (HR 2.07, p =.06) and breast cancer (HR 2.37, p =.07). More than one metastasis is an independent predictor of local and leptomeningeal failure following postoperative radiosurgery. The high rate of LMD was likely related to the liberal definition of LMD to include focal dural recurrences.
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    Digital Object Identifier (doi)

    Author List

  • Foreman PM; Jackson BE; Singh KP; Romeo AK; Guthrie BL; Fisher WS; Riley KO; Markert JM; Willey CD; Bredel M
  • Start Page

  • 48
  • End Page

  • 55
  • Volume

  • 49